New research suggests that individuals who stop using new GLP-1 drugs like semaglutide or tirzepatide can put back on shed pounds much more quickly than those who stop traditional diet and exercise programs.
Published data in a prominent health publication demonstrates that while obese people can lose substantial amounts of their total mass while on the medication, the weight comes back at an average rate of nearly a kilo each month upon discontinuation.
"Individuals buying such treatments should be informed of the potential of rapid rebound weight gain when the treatment ends," stated expert Dr. Susan Jebb.
This pace of recovery means a return to starting weight within about one and a half years.
Analyzing Treatments
The research, which looked at dozens of trials involving over 9,000 of patients, compared the results of these new drugs with older methods.
Researchers point out that individuals who lose weight through lifestyle changes alone typically have a less rapid weight regain—around 0.1 kg a month—after stopping.
The Reason for the Rapid Regain
Doctors propose the mechanism of the injections explains the amplified regain.
These medications imitate a natural hormone called GLP-1, which helps regulate appetite.
"Artificially providing GLP-1 levels several times higher than normal might result in the body to produce less of its own natural GLP-1, and may also lessen sensitivity to its actions," noted Dr. Adam Collins, a nutrition researcher.
"Withdrawal of this medication leads to hunger is uncontrolled, making excessive eating a significant risk."
A Lifelong Issue?
The NHS suggest the injections for people with obesity-related health risks, accompanied by recommended diet and exercise modifications.
Many experts say that, considering the high risk of relapse, the therapy should be considered long-term.
This perspective is reinforced by pharmaceutical companies, who state that the results "highlight the chronic nature of excess weight," similar to managing conditions like diabetes.
User Testimonies
People who have discontinued the medication explain a intense return of cravings.
"I experienced a switch activating and you become extremely hungry," recalled one woman.
This challenge is worsened if users have not developed lasting dietary or behavioural changes during treatment.
Growing Interest
Recent estimates indicate that millions of adults in the UK have tried weight-loss jabs in the past year, with interest continuing to grow.
- Use is more common among females than males.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion access the drugs through private prescriptions rather than public health services.
Finally, researchers stress that while these medications are powerful tools for weight loss, they are not a magic cure and lasting health benefits likely depends on integrated lifestyle changes.
